Last Supper for Mosquitoes

نویسندگان

  • M. Sawada
  • Y. Matsui
  • Y. Okudaira
چکیده

Cis-Diamminedichloroplatinum II (CDDP) has been recognized as one of the most active drugs against malignant tumours including ovarian cancer. However, CDDP is a toxic drug causing emesis, renal failure, hearing loss, neuropathy and anaemia. In view of these toxicities many investigators have attempted to develop new platinum analogues which retain anti-tumour activity with less toxicity. Among a large number of platinum analogues, cis-diammine-l, 1-cyclobutane dicarboxylate platinum II (CBDCA) and cis-dichloro-trans-dihydroxy-bisisopropylamine platinum IV (CHIP) have been selected as promising compounds and projected for clinical trials (Calvert et al., 1982; Creaven et al., 1983). There have been several reports on the clinical efficacy of CBDCA and CHIP as anti-cancer drugs. However, few studies have reported the simultaneous testing of the antitumour activities of CBDCA, CHIP and CDDP against heterotransplanted human tumours (WolpertDeFilippes, 1980; Harrap et al., 1980; Boven et al., 1985). These reports revealed that ovarian undifferentiated carcinoma (Boven et al., 1985) and epidermoid carcinoma (Harrap et al., 1980) responded to CBDCA, whereas colon, lung and mammary xenografted tumours were generally refractory to new platinum analogues including CBDCA and CHIP (Wolpert-DeFilippes, 1980). In 1977, we successfully transplanted tissues from human yolk sac tumours of the ovary into nude mice, and three of these have been maintained by serial transplantation in nude mice in our laboratory (Sawada et al., 1981; 1982). We previously reported that the tumours responded well to CDDP combination chemotherapy (Sawada et al., 1983). In this preliminary study, we have examined the therapeutic responses of ovarian yolk sac tumours to CBDCA, CHIP and CDDP. The human yolk sac tumours (YST-1, YST-2 and

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عنوان ژورنال:
  • Environmental Health Perspectives

دوره 106  شماره 

صفحات  -

تاریخ انتشار 1998